FUNCTIONALIZED N-ACETYLGALACTOSAMINE ANALOGS

FUNCTIONALIZED N-ACETYLGALACTOSAMINE ANALOGS

Embodiments of the present application relate to functionalized N-acetylgalactosamine analogs, methods of making, and uses of the same. In particular, polyvalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-...

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Bibliographische Detailangaben
Hauptverfasser: Yu, Guijun, Zhao, Gang, Poon, Wing C, Yu, David, Yao, Yun-Chiao, Du, Gengyu, Li, Zhixia, Lau, Aldrich N.K, Zou, Ruiming
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
SUGARS
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Zusammenfassung:Embodiments of the present application relate to functionalized N-acetylgalactosamine analogs, methods of making, and uses of the same. In particular, polyvalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.