COMPOSITIONS AND METHODS FOR INHIBITING KRAS

COMPOSITIONS AND METHODS FOR INHIBITING KRAS

Provided herein are compounds of formula (I) and (II), or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chan, Albert Hay Wah, Lightstone, Felice, Wang, Bin, Wallace, Eli, Maciag, Anna Elzbieta, Turner, David Michael, Simanshu, Dhirendra Kumar, Xu, Rui, Zhang, Zuhui, Yang, Yue, Liao, Tao, Bisignano, Paola, Brassard, Christopher John
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Provided herein are compounds of formula (I) and (II), or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12D mutation) and treating diseases or disorders such as cancers in subjects in need thereof.