FC VARIANT WITH HIGH THERMAL STABILITY AND ATTENUATED EFFECTOR FUNCTION

FC VARIANT WITH HIGH THERMAL STABILITY AND ATTENUATED EFFECTOR FUNCTION

A polypeptide comprising one or more variant Fc regions, each of the variant Fc regions comprising two CH2 domains, wherein at least one of the CH2 domains in at least one of the variant Fc regions is a variant CH2 domain, and wherein amino acid residues at positions 234, 235, and 265 (all positions...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Shinozaki, Naoya, Makino, Tomohiro, Nagaoka, Nobumi
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:A polypeptide comprising one or more variant Fc regions, each of the variant Fc regions comprising two CH2 domains, wherein at least one of the CH2 domains in at least one of the variant Fc regions is a variant CH2 domain, and wherein amino acid residues at positions 234, 235, and 265 (all positions expressed by EU numbering) of the variant CH2 domain are Ala, Ala, and Gly, or Ala, Ala, and Asn, respectively.