A METHOD OF IMPROVING STABILITY OF AN ANTIBODY FORMULATION

The present invention discloses a stable formulation of an α4β7 antibody, wherein the formulation comprises α4β7 antibody, amino acid, a mono carboxylic acid or dicarboxylic acid or dicarboxylic acid, and surfactant. The disclosed antibody formulations are liquid high concentration formulations that...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	INGALE, Mahesh, VASUDEO PAKHALE, Swapnil, GHOSH, Shrija, LABALA, Suman, JAYARAMAN, Murali, SAHA, Ananya, R. L., Shri Ranga Priya
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention discloses a stable formulation of an α4β7 antibody, wherein the formulation comprises α4β7 antibody, amino acid, a mono carboxylic acid or dicarboxylic acid or dicarboxylic acid, and surfactant. The disclosed antibody formulations are liquid high concentration formulations that are also suitable for different mode of administration (subcutaneous/intravenous). The disclosed formulations exhibit stability under various accelerated stress conditions.