ANTICANCER THERAPY

The present invention relates to a Son of Sevenless 1 (SOS1) inhibitor and/or a mitogen-activated protein kinase kinase (MEK) inhibitor for use in the treatment and/or prevention of cancer, wherein the SOS1 inhibitor or the MEK inhibitor is administered alone or the SOS1 inhibitor is administered in...

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Bibliographische Detailangaben
Hauptverfasser:	MITSUDOMI, Tetsuya, HOFMANN, Marco Hans, GMACHL, Michael, KOGA, Takamasa
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to a Son of Sevenless 1 (SOS1) inhibitor and/or a mitogen-activated protein kinase kinase (MEK) inhibitor for use in the treatment and/or prevention of cancer, wherein the SOS1 inhibitor or the MEK inhibitor is administered alone or the SOS1 inhibitor is administered in combination with the MEK inhibitor, wherein the cancer is resistant to treatment with an inhibitor of KRAS G12C.