CD70 ANTI-IDIOTYPE ANTIBODIES

Provided herein are anti-idiotype antibodies that specifically recognize anti-CD70 antibody moieties, in particular, anti-CD70 antibody moieties present in recombinant receptors, including chimeric antigen receptors (CARs). The disclosure further relates to uses of anti-idiotype antibodies for speci...

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Bibliographische Detailangaben
Hauptverfasser:	PANOWSKI, Siler, SRIVATSA SRINIVASAN, Surabhi, MELTON, Zea, VAN BLARCOM, Thomas John
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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Beschreibung
Zusammenfassung:	Provided herein are anti-idiotype antibodies that specifically recognize anti-CD70 antibody moieties, in particular, anti-CD70 antibody moieties present in recombinant receptors, including chimeric antigen receptors (CARs). The disclosure further relates to uses of anti-idiotype antibodies for specifically identifying and/or selecting cells expressing such recombinant receptors, such as anti-CD70 CAR T cells. The disclosure further relates to uses of anti-idiotype antibodies for specifically activating such cells.