SUBSTITUTED FUSED AZINES AS KRAS G12D INHIBITORS

SUBSTITUTED FUSED AZINES AS KRAS G12D INHIBITORS

The present invention provides compounds of the formula where R1, R2, R3, R4a, R4b, R4c, R5, R6, X, Y, and Z are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.

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Bibliographische Detailangaben
Hauptverfasser: CLAYTON, Joshua Ryan, RODRIQUEZ, Michael John, JOHNSTON, Richard Duane, LAMAR, Jason Eric, FURNESS, Kelly Wayne, RUBIO, Almudena, ZHAO, Gaiying, BARDA, David Anthony, FRANCISKOVICH, Jeffry Bernard, GERNERT, Douglas Linn, ZIA-EBRAHIMI, Mohammed Sadegh, SI, Chong, JONES, Spencer Brian, MBOFANA, Curren Tapfuma, HENRY, James Robert, LEVINSON, Adam Marc
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides compounds of the formula where R1, R2, R3, R4a, R4b, R4c, R5, R6, X, Y, and Z are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.