APTAMER-TYPE MULTI-WARHEAD COVALENT DRUG

The invention imparts new properties to nucleic acid aptamers, which may enhance its function as therapeutic drugs or the like. Also provided is a covalent drug having the new properties as an anti-SARS-COV-2 drug. Specifically, an aptamer-based multiwarhead covalent drug having multiple covalent bi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	YANG, Jay, TABUCHI, Yudai, TAKI, Masumi
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention imparts new properties to nucleic acid aptamers, which may enhance its function as therapeutic drugs or the like. Also provided is a covalent drug having the new properties as an anti-SARS-COV-2 drug. Specifically, an aptamer-based multiwarhead covalent drug having multiple covalent binding warheads is provided. In particular, an aptamer-based multiwarhead covalent drug targeting SARS-COV-2 is provided. A pharmaceutical composition comprising the multiwarhead nucleic acid aptamer and a method of producing the multiwarhead nucleic acid aptamer are also provided.