Methods of Producing Sulfated Oligosaccharide Derivatives and Intermediates Thereof

Methods of Producing Sulfated Oligosaccharide Derivatives and Intermediates Thereof

The invention relates inter alia to methods of producing sulfated oligosaccharide derivatives and intermediates thereof. The sulfated oligosaccharide derivatives may be represented by the following formula (I):[X]nY−ZR1R2Formula (I)wherein:X and Y are any D- or L-hexose or pentose, wherein each hydr...

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Bibliographische Detailangaben
Hauptverfasser: ROWLEY, Jessica Anne, WALLIS, Laura, CLARKSON, Robert, KAROLI, Tomislav, GALE, Helen, HANDLEY, Paul Newton, WEYMOUTH-WILSON, Alexander, TYRRELL, Andrew, WHITE, Aileen, FRANKS, Helen, GREENWOOD, Phillip
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Beschreibung
Zusammenfassung:The invention relates inter alia to methods of producing sulfated oligosaccharide derivatives and intermediates thereof. The sulfated oligosaccharide derivatives may be represented by the following formula (I):[X]nY−ZR1R2Formula (I)wherein:X and Y are any D- or L-hexose or pentose, wherein each hydroxyl group not involved in a glycosidic linkage is substituted by a group W, and Y has an anomeric carbon atom;W is SO3M, and M is any pharmaceutically acceptable cation;n is an integer from 2 to 6;Z is O, and is linked to the anomeric carbon atom of Y; andR1R2 together form a lipophilic moiety.