DIRECT IMAGING METHOD FOR BLOOD CELLS FLOWING IN VASCULAR NETWORK

A direct imaging method for blood cells flowing in a vascular network is provided. The direct imaging method includes obtaining sequential images of a biological sample; generating blood cell images by removing a background signal from the sequential images; generating images without speckle noise by using spatially incoherent illumination; obtaining high-speed and high sensitivity imaging by using a high-speed camera with a high full-well capacity; generating a vascular structure image of the biological sample using the blood cell images; generating a blood cell trajectory image based on trajectories of blood cells moving along a vascular network identified in the vascular structure image through the blood cell images; and obtaining hemodynamic information based on the blood cell trajectory image.