MACROCYCLES AS CFTR MODULATORS

The present invention relates to macrocyclic compounds of Formula (I)wherein Ar1, Ar2, R1, R2, R3, R4, and X are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or mor...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	WAGNER, Clemens, BOLLI, Martin, KIMMERLIN, Thierry, SIENDT, Hervé, BROTSCHI, Christine, COMMANDEUR, Malgorzata, WILLIAMS, Jodi T, SPRINGER, Jasper, GATFIELD, John, WEGERT, Anita
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to macrocyclic compounds of Formula (I)wherein Ar1, Ar2, R1, R2, R3, R4, and X are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as modulators of CFTR.