ENGINEERED INFLUENZA VIRUSES EXPRESSING SARS-COV-2 ANTIGENS, VACCINES AND METHODS OF MAKING AND USING THE SAME

The present invention provides engineered polynucleotides encoding both the receptor binding domain (RBD) of a SARS-CoV-2 spike protein and an influenza hemagglutinin (HA) protein. Also provided are influenza viruses that comprise the engineered polynucleotides and express both the RBD and HA protei...

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Bibliographische Detailangaben
Hauptverfasser:	Harding, Alfred, Heaton, Nicholas, Heaton, Brook, Chaparian, Ryan
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides engineered polynucleotides encoding both the receptor binding domain (RBD) of a SARS-CoV-2 spike protein and an influenza hemagglutinin (HA) protein. Also provided are influenza viruses that comprise the engineered polynucleotides and express both the RBD and HA protein on their surface and methods for using these influenza viruses to generate an immune response to both influenza and SARS-CoV-2 in a subject.