Manufacturing a Therapeutic Device and System containing a plurality of cells

A method of manufacturing a therapeutic device includes providing a member that defines first pores having a first average size that (i) allows passage of a therapeutic agent through the first pores and (ii) prevents passage of immune cells through the first pores. The method further includes spinning the member about an axis of the member and applying a fibrous material to the member while the member spins to form a coating that surrounds the member. The coating defines second pores having a second average size that is larger than the first average size, and the second pores are sized to promote vascularization along the coating. The member and the coating together form a container of the therapeutic device, and the container defines an interior region for accommodating a plurality of cells capable of producing the therapeutic agent.