Determining physical parameters of a liquid with simulation
A method for determining physical parameters of an unknown liquid to be aspirated and/or dispensed by a laboratory automation device comprises: determining physical parameters of a pipette, the physical parameters including geometric parameters of the pipette, which at least include a tip radius of...
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Sprache: | eng |
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Zusammenfassung: | A method for determining physical parameters of an unknown liquid to be aspirated and/or dispensed by a laboratory automation device comprises: determining physical parameters of a pipette, the physical parameters including geometric parameters of the pipette, which at least include a tip radius of an orifice of the pipette; aspirating and/or dispensing the unknown liquid with a pipette of the laboratory automation device and measuring a measured pressure curve in the pipette during aspirating and/or dispensing; determining the physical parameters of the unknown liquid by minimizing an objective function depending on a difference between a simulated pressure curve and the measured pressure curve, wherein the simulated pressure curve simulates a pressure in the pipette during aspirating and/or dispensing and is calculated based on a physical model of the laboratory automation device including the physical parameters of the pipette. |
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