COLLAGEN HYDROGELS USEFUL AS CELL CARRIERS

A collagen hydrogel which has a 3D fibrillar structure with micropores obtainable by a process including: providing an acidic mass of native Type I collagen fibers dispersed in water in a concentration comprised between 1-15% in weight; b) neutralizing the acidic mass to adjust the pH to physiologic...

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Bibliographische Detailangaben
Hauptverfasser:	Izco Zaratiegui, Jesús Maria, Guembe Lapuente, Amaia, Recalde Irurzun, José Ignacio, Zúñiga Arrarás, Teresa
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ENZYMOLOGY HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A collagen hydrogel which has a 3D fibrillar structure with micropores obtainable by a process including: providing an acidic mass of native Type I collagen fibers dispersed in water in a concentration comprised between 1-15% in weight; b) neutralizing the acidic mass to adjust the pH to physiological pH; and c) applying beta radiation in a range of up to 50 KGy; wherein the acidic mass has a pH between 0.5-5; and fibers, wherein the acidic mass includes fibers, wherein at least 90% of the total mass of the fibers have a length in of 1 μm to 2500 μm and a fiber diameter of from 0.1 to 150 μm measured at a pH between 1 and 2. A process for its preparation as well as its use as support for cell tissue or as scaffold of cultured meat, as well as the hydrogel for use in biomedical applications.