MACROCYCLE COMPLEMENT FACTOR B INHIBITORS

This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases or disorders related to misregulation of the Complement cascade pathway. More particularly, this disclosure relates to macrocyclic compounds an...

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Bibliographische Detailangaben
Hauptverfasser:	Wiles, Jason Allan, Gadhachanda, Venkat Rao
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases or disorders related to misregulation of the Complement cascade pathway. More particularly, this disclosure relates to macrocyclic compounds and pharmaceutical compositions thereof, methods of inhibiting Complement Factor B (CFB) expression with these compounds, and methods of treating diseases or disorders mediated by CFB.