METHODS OF DESIGNING AN ORAL DRUG DOSAGE FORM BASED ON A TARGET PK PROFILE AND DOSAGE FORMS THEREOF

The present disclosure, in some aspects, is directed to methods of deisgning an oral drug dosage form formulated and configured to provide an efficacy-based target pharmocokinetic (PK) profile by optmizing the drug concentration-permeability interplay at any time and/or location in the gastrointesti...

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Bibliographische Detailangaben
Hauptverfasser:	CAO, Lihua, CHENG, Senping, LIU, Xin, LI, Xiaoling, LIU, Xipan, DENG, Feihuang
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEDICAL OR VETERINARY SCIENCE NANOTECHNOLOGY PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES TRANSPORTING
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Beschreibung
Zusammenfassung:	The present disclosure, in some aspects, is directed to methods of deisgning an oral drug dosage form formulated and configured to provide an efficacy-based target pharmocokinetic (PK) profile by optmizing the drug concentration-permeability interplay at any time and/or location in the gastrointestinal tract. In other aspects, the present disclosure is directed to oral drug dosage forms having the desired PK profile, and methods of making, such as three-dimentional printing, such oral drug dosage forms to release the drug (and any functional excipients) with the right amount, at the right time, and at the right location.