METHODS OF DETECTING SYSTEMIC AMYLOIDOSIS VIA BINDING TO MISFOLDED OR AGGREGATED PROTEIN

METHODS OF DETECTING SYSTEMIC AMYLOIDOSIS VIA BINDING TO MISFOLDED OR AGGREGATED PROTEIN

Provided herein are methods and compositions for determining whether a patient suffers from systemic amyloidosis, comprising detecting the presence of a misfolded or aggregated protein in a tissue of the patient, wherein the detecting comprises contacting the misfolded or aggregated transthyretin pr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Vanderklish, Peter W, Sarraf, Stella T, Tafreshi, Ali
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
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Beschreibung
Zusammenfassung:Provided herein are methods and compositions for determining whether a patient suffers from systemic amyloidosis, comprising detecting the presence of a misfolded or aggregated protein in a tissue of the patient, wherein the detecting comprises contacting the misfolded or aggregated transthyretin protein with a compound described herein. In some embodiments, the misfolded or aggregated protein is transthyretin.