SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES
Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of prep...
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| creator | RAYMOND, Donald WEI, Jianmei CHAI, Wenying CHUNG, De Michael SUNDBERG, Thomas BACANI, Genesis M HIRST, Gavin SEIERSTAD, Mark VENABLE, Jennifer D KAUSHIK, Virnedar XAVIER, Ramnik STEFFENS, Helena C TICHENOR, Mark S GOLDBERG, Steven D SMITH, Russel C MERCADO-MARIN, Eduardo V |
| description | Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs. |
| format | Patent |
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In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES |
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