SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES

SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES

Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of prep...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: RAYMOND, Donald, WEI, Jianmei, CHAI, Wenying, CHUNG, De Michael, SUNDBERG, Thomas, BACANI, Genesis M, HIRST, Gavin, SEIERSTAD, Mark, VENABLE, Jennifer D, KAUSHIK, Virnedar, XAVIER, Ramnik, STEFFENS, Helena C, TICHENOR, Mark S, GOLDBERG, Steven D, SMITH, Russel C, MERCADO-MARIN, Eduardo V
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.