CK1 alpha AND DUAL CK1 alpha / GSPT1 DEGRADING COMPOUNDS

CK1 alpha AND DUAL CK1 alpha / GSPT1 DEGRADING COMPOUNDS

Provided herein are compounds that act as molecular glues, inducing degradation of CK1α or CK1α/GSPT1, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject with a prolifer...

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Bibliographische Detailangaben
Hauptverfasser: Sapienza, John, Haughey, Michael P, Elsner, Jan, Plantevin-Krenitsky, Veronique, Xie, Weilin, Mendy, Derek, Mercurio, Frank, Krenitsky, Paul J, Papa, Patrick W
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Provided herein are compounds that act as molecular glues, inducing degradation of CK1α or CK1α/GSPT1, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject with a proliferative disease.