HETEROBIFUNCTIONAL INHIBITORS OF E-SELECTIN AND GALECTIN-3

HETEROBIFUNCTIONAL INHIBITORS OF E-SELECTIN AND GALECTIN-3

Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin, galectin-3, or E-selectin and galectin-3 to ligands are disclosed. For example, heterobifunctional inhibitors of E-selectin and galectin-3...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: NOGUEIRA, Jason, MAGNANI, John L, VOHRA, Yusufbhai U, PETERSON, John M, GHOSH, Indranath, SARKAR, Arun K
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin, galectin-3, or E-selectin and galectin-3 to ligands are disclosed. For example, heterobifunctional inhibitors of E-selectin and galectin-3 are described and pharmaceutical compositions comprising at least one such agent is described.