Access System Including Flexible Needle

Embodiments disclosed herein are directed to an access system including a flexible needle configured to negotiate a non-linear pathway to access a subcutaneous port. Optionally, the access system can include a needle guide to facilitate alignment of the needle with the subcutaneous port. The needle can be configured to be flexible enough to have some bending, or deflection capability but also possess sufficient columnar strength to prevent buckling when piercing the skin and entering the port. The flexible needle can be deflected from a central axis to overcome any misalignment with the receiving cup and/or conduit of the port. Once within the port conduit the needle can negotiate the non-linear, or tortuous port conduit pathway, and stream-line the insertion procedure.