COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF

COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF

The disclosure features macrocyclic compounds, alone and in combination with other therapeutic agents, as well as pharmaceutical compositions and protein complexes thereof, capable of modulating biological processes including RAS and RAS-RAF inhibition, and their uses in the treatment of cancers.

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Bibliographische Detailangaben
Hauptverfasser: Koltun, Elena S, Yin, Ning, Ahn, Jae Young, Lowe, Jason T, JIN, Meizhong, Perl, Nicholas, Mulvihill, Mark Joseph, Kohlmann, Anna, Gill, Adrian L
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The disclosure features macrocyclic compounds, alone and in combination with other therapeutic agents, as well as pharmaceutical compositions and protein complexes thereof, capable of modulating biological processes including RAS and RAS-RAF inhibition, and their uses in the treatment of cancers.