OPTICAL STABILIZATION TECHNIQUES INCORPORATING PIXEL CURRENT MEASUREMENTS

Described herein are techniques for determining an illumination position on an integrated photodetector, as may be used within a fluorescence detection system. In some embodiments, such techniques may include determining an illumination position on an integrated photodetector based, at least in part, on a measurement of an amount of current output from a pixel of the integrated photodetector, the amount of current corresponding to an amount of excitation light (e.g., used for exciting fluorescence in a sample) that is received at the pixel. In some embodiments, such techniques may include measuring an amount of current output from one or more drain regions of one or more pixels of an integrated photodetector (e.g., regions used to draw away charge carriers corresponding to excitation light so as to not pollute collected charge carriers that correspond to fluorescence light to be detected).