topical formulation of Disease-Modifying Antirheumatic Drug (DMARDs) for treatment of rheumatoid arthritis, melanoma, squamous cell carcinoma, atopic dermatitis and psoriasis

The present invention relates to a composition of disease-modifying antirheumatic drugs (DMARDs) for treatment of auto-immune diseases. More particularly, the invention relates to the microemulsion based emulgel composition of DMARD-leflunomide or its derivatives for treatment of auto-immune disease...

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Bibliographische Detailangaben
Hauptverfasser:	Shidhaye, Supriya Shrihari, Parab, Bhagyashri Surendra, Korlekar, Pradnya Nikhil, Karia, Palak, Ayre, Anita Pandurang, Nagarsenkar, Mangal Shailesh, Jadhav, Manoj Purushottam, Tank, Shivali Hargovind
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to a composition of disease-modifying antirheumatic drugs (DMARDs) for treatment of auto-immune diseases. More particularly, the invention relates to the microemulsion based emulgel composition of DMARD-leflunomide or its derivatives for treatment of auto-immune diseases such as rheumatoid arthritis, atopic dermatitis, psoriasis and skin cancer such as melanoma, squamous cell carcinoma. The invention also discloses a method for preparation of microemulsion based emulgel composition with improved physicochemical, pharmacokinetic properties of leflunomide to be used in pharmaceutical compositions. This invention discloses the delivery of leflunomide across human skin for the treatment of autoimmune and oncological conditions. The unique delivery of leflunomide in the form of microemulsion based emulgel composition is disclosed.