Attenuating bacterial virulence by attenuating bacterial folate transport

The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed against Streptococcus infections in pigs. The invention provides a ΔFolT mutant of a bacterium having reduced capacity to tr...

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Hauptverfasser: DE GREEFF, Astrid, INGEBRITSON, Alaina, SMITH, Hilda Elizabeth, NEUBAUER, Axel
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creator DE GREEFF, Astrid
INGEBRITSON, Alaina
SMITH, Hilda Elizabeth
NEUBAUER, Axel
description The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed against Streptococcus infections in pigs. The invention provides a ΔFolT mutant of a bacterium having reduced capacity to transport folate, wherein said capacity has been reduced by functionally deleting folate transporter (FolT) function. The invention also provides a method to reduce virulence of a bacterium comprising reducing the capacity of said bacterium to transport folate.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Attenuating bacterial virulence by attenuating bacterial folate transport
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