REAGENTS FOR DETECTION OF N-GLYCOSYLATION
An asparagine-linked glycan (N-glycan) detection reagent is provided that utilizes Fbs variants engineered from mouse Fbs proteins, wherein the Fbs variants bind specifically to N-glycosylated peptides and proteins and not to non-glycosylated peptides and proteins, including wherein the Fbs variants...
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| creator | Meng, Lu Yang, Loretta Wu, Shengcheng Gerner-Smidt, Christian Woods, Robert J Abnouf, Shaza |
| description | An asparagine-linked glycan (N-glycan) detection reagent is provided that utilizes Fbs variants engineered from mouse Fbs proteins, wherein the Fbs variants bind specifically to N-glycosylated peptides and proteins and not to non-glycosylated peptides and proteins, including wherein the Fbs variants bind to N-glycosylated peptides and proteins and not to corresponding non-glycosylated versions of the same peptides and proteins. Compositions and methods for developing and using N-glycosylation-specific analytical, diagnostic, and therapeutic tools are provided. |
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| subjects | CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SEPARATION THEIR RELEVANT APPARATUS TRANSPORTING |
| title | REAGENTS FOR DETECTION OF N-GLYCOSYLATION |
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