REAGENTS FOR DETECTION OF N-GLYCOSYLATION

REAGENTS FOR DETECTION OF N-GLYCOSYLATION

An asparagine-linked glycan (N-glycan) detection reagent is provided that utilizes Fbs variants engineered from mouse Fbs proteins, wherein the Fbs variants bind specifically to N-glycosylated peptides and proteins and not to non-glycosylated peptides and proteins, including wherein the Fbs variants...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Meng, Lu, Yang, Loretta, Wu, Shengcheng, Gerner-Smidt, Christian, Woods, Robert J, Abnouf, Shaza
Format: Patent
Sprache:eng
Schlagworte:
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
SEPARATION
THEIR RELEVANT APPARATUS
TRANSPORTING
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Beschreibung
Zusammenfassung:An asparagine-linked glycan (N-glycan) detection reagent is provided that utilizes Fbs variants engineered from mouse Fbs proteins, wherein the Fbs variants bind specifically to N-glycosylated peptides and proteins and not to non-glycosylated peptides and proteins, including wherein the Fbs variants bind to N-glycosylated peptides and proteins and not to corresponding non-glycosylated versions of the same peptides and proteins. Compositions and methods for developing and using N-glycosylation-specific analytical, diagnostic, and therapeutic tools are provided.