MAINTENANCE OF PROGRAMMED CHRONIC LIVER INJURY OF FAH GENE-DEFICIENT ANIMALS AND APPLICATION THEREOF IN PREPARATION OF HETEROLOGOUS LIVER MODELS

Provided in the present invention are the maintenance of the programmed chronic liver injury of FAH gene-deficient animals and an application thereof in the preparation of heterologous liver models. The present invention discloses a programmed NTBC controlling (NTBCP) scheme with a fixed cycle perio...

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Bibliographische Detailangaben
Hauptverfasser:	Zheng, Yunwen, GE, Jianyun, Liu, Liping
Format:	Patent
Sprache:	eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY CARE OF BIRDS, FISHES, INSECTS FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE NEW BREEDS OF ANIMALS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRAPPING
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Beschreibung
Zusammenfassung:	Provided in the present invention are the maintenance of the programmed chronic liver injury of FAH gene-deficient animals and an application thereof in the preparation of heterologous liver models. The present invention discloses a programmed NTBC controlling (NTBCP) scheme with a fixed cycle period, the scheme enabling animal models to survive for a long time in a state of chronic liver injury, and being capable of achieving a high heterologous replacement rate after a heterologous hepatocyte transplantation is performed.