HIGH-DYNAMIC RANGE SCANS (OVERLAPPING WINDOWS)

Methods for acquiring mass spectral data comprise determining first and second sets of m/z sub-ranges comprising respective first and second m/z sub-ranges. A sample is mass filtered to isolate ions in the first and second sets of m/z sub-ranges using respective mass filters. Mass analysis is performed to obtain first and second partial mass spectral data sets, the first and second mass filters having first and second response profiles having respective relatively high transmission regions and one or more relatively low transmission regions. The first and second sets of m/z sub-ranges are determined such that relatively high transmission regions of the first response profile and the second response profile at least partially overlap.