NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS

Invented are compounds of formula Iand the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to t...

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Bibliographische Detailangaben
Hauptverfasser: Lim, Yeon-Hee, Ding, Fa-Xiang, Mak, Victor W, Roane, James Patrick, Bao, Jianming, Hugelshofer, Cedric Lorenz, Shockley, Samantha E, Yen, Rose, Sanzone, Jillian R, Cruz, Faben A
Format: Patent
Sprache:eng
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Zusammenfassung:Invented are compounds of formula Iand the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, type-2 diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cognitive decline, dementia, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions, comprising administering a compound of Formula I to a patient in need thereof.