BCL-XL Inhibitory Compounds Having Low Cell Permeability and Antibody Drug Conjugates Including the Same

BCL-XL Inhibitory Compounds Having Low Cell Permeability and Antibody Drug Conjugates Including the Same

The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for synthesizing the ADCs, compositions comprising the inhibitors or ADCs, and various methods of using the inhibitors and ADCs.

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Bibliographische Detailangaben
Hauptverfasser: Sullivan, Gerard M, Welch, Dennie S, Judd, Andrew S, Bennett, Nathan B, Cullen, Steve C, Kunzer, Aaron R, Doherty, George, Wang, Xilu, Tao, Zhi-Fu, Marin, Violeta L, Song, Xiaohong, Wendt, Michael D, Frey, Robin R, Boghaert, Erwin R, Haight, Anthony R, Ackler, Scott L, Shen, Xiaoqiang, Souers, Andrew J
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for synthesizing the ADCs, compositions comprising the inhibitors or ADCs, and various methods of using the inhibitors and ADCs.