BIOACTIVE COCHLEAR IMPLANT AND APPLICATIONS OF SAME

In one aspect, this invention relates to a bioactive implant comprising an electrode array; and a source of neurotrophins coupled with the electrode array for generating a neurotrophin concentration gradient that facilitates a neuro-regenerative nexus (NRN) for survival, neuronal differentiation tow...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Jones, Michael, Nella, Kevin Tomy, Matsuoka, Akihiro J
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ELECTROTHERAPY ENZYMOLOGY HUMAN NECESSITIES HYGIENE MAGNETOTHERAPY MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS RADIATION THERAPY SPIRITS ULTRASOUND THERAPY VINEGAR WINE
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Beschreibung
Zusammenfassung:	In one aspect, this invention relates to a bioactive implant comprising an electrode array; and a source of neurotrophins coupled with the electrode array for generating a neurotrophin concentration gradient that facilitates a neuro-regenerative nexus (NRN) for survival, neuronal differentiation toward spiral ganglion neurons (SGNs), and directed neurite extension of human pluripotent stem cell (hPSC)-derived SGNs. The invention in another aspect also relates to a method for realization of the NRN in conjunction with an implant, comprising coupling a source of neurotrophins with the electrode array to generate a neurotrophin concentration gradient that facilitates the NRN for survival, neuronal differentiation toward SGNs, and directed neurite extension of hPSC-derived SGNs.