PIPERIDINYL SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE

PIPERIDINYL SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE

Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the co...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Liu, Hu, Petrilli, Whitney, Zhang, Tinghu, Che, Jianwei, Jones, Lyn, Bear, Brian
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders associated with Helios and which may benefit from Helios degradation.