MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharma...

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Bibliographische Detailangaben
Hauptverfasser:	ZHOU, Jinglan, HADIDA RUAH, Sara Sabina, MCCARTNEY, Jason, MILLER, Mark Thomas, ARUMUGAM, Vijayalaksmi, CLEVELAND, Thomas, TRAN, Joe A, DWIGHT, Timothy A, GROOTENHUIS, Peter, FANNING, Lev Tyler Dewey, DINH, Andrew, FRIEMAN, Bryan A, ABRAHAM, Sunny, SILINA, Alina, KRENITSKY, Paul, PIERRE, Fabrice, ANDERSON, Corey Don, COON, Timothy Richard, VALDEZ, Lino, CLEMENS, Jeremy, ISHIHARA, Yoshihiro, ABELA, Alexander Russell, CHAU, Jaclyn
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.