ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE

ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE

The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I):or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7,...

Ausführliche Beschreibung

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Hauptverfasser: DAWADI, Surendra, ANDERSON, Erin Danielle, CHAN, Warren Christopher, SAINZ, Marcos Adrian, POTOTSCHNIG, Gerit Maria, SUN, Zhicheng, KOLAKOWSKI, Gabrielle R, MURHADE, Ganesh Mangalsing, WRIGHT, Nathan Edward, CHEN, Shuai, WANG, Xia, SCAGGS, LaToya Denise, IRVIN, Thomas Combs, WELCH, Michael Brian, LONG, Katelyn Frances, ARONOW, Sean Douglas, WANG, Hua-Yu, JETTE, Carina Ivonne, PICADO, Alfredo, KUMAR, Manoj, MAYNE, Christopher Glenn, KESICKI, Edward A, SAMMAKIA, Tarek
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I):or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.