MODIFIED OLIGONUCLEOTIDES FOR USE IN TREATMENT OF TAUOPATHIES

Oligonucleotides comprising modifications at the 2′ and/or 3′ positions(s) along with methods of making and use against Alzheimer disease and other tauopathies are disclosed.

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Bibliographische Detailangaben
Hauptverfasser: BEIGELMAN, Leonid, MARTINEZ MONTERO, Saúl, RAJWANSHI, Vivek Kumar, EBNETH, Andreas, GRYAZNOV, Sergei, VAN OUTRYVE D'YDEWALLE, Constantin
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Oligonucleotides comprising modifications at the 2′ and/or 3′ positions(s) along with methods of making and use against Alzheimer disease and other tauopathies are disclosed.