NOVEL SYNTHETIC PATHWAY TO BELZUTIFAN

The disclosure provides a novel process and synthetic intermediates for making belzutifan, a HIF-2a inhibitor, useful for the treatment of certain VHL-related indications and cancer.

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Bibliographische Detailangaben
Hauptverfasser:	Winston, Matthew S, McMullen, Jonathan P, Morris, William, McCann, Scott D, McIntosh, John, Zhang, Victoria, Zhong, Yong-Li, Chun, Stephanie W, Moore, Jeffrey C, Cheung-Lee, Wai Ling, Kim, Jungchul, Kosjek, Birgit, DiRocco, Daniel A, Cahn, Jackson Kenai Blender, Johnson, Heather Claire, Hethcox, J. Caleb, Kolev, Joshua N, Le, Diane, Velasquez Velez, Juan Esteban
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The disclosure provides a novel process and synthetic intermediates for making belzutifan, a HIF-2a inhibitor, useful for the treatment of certain VHL-related indications and cancer.