PCR METHOD AND KIT FOR DETERMINING PATHWAY ACTIVITY

The present invention relates to assemblies of primers and probes for determining the cellular signalling pathway of the AR pathway and optionally the activities of the pathways ER, PI3K-FOXO, MAPK-AP1, Notch, HH, TGFbeta, JAK-STAT1/2 and NFkB. Kit or use of the set of 3 or more primers and probes t...

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Hauptverfasser:	DEN BIEZEN, Eveline Catharina Anna Clasina, VAN STRIJP, Dianne Arnoldina Margaretha Wilhelmina, VAN BRUSSEL, Anne Godefrida Catharina, HOLTZER, Laurentius Henricus Franciscus Maria, WROBEL, Janneke
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to assemblies of primers and probes for determining the cellular signalling pathway of the AR pathway and optionally the activities of the pathways ER, PI3K-FOXO, MAPK-AP1, Notch, HH, TGFbeta, JAK-STAT1/2 and NFkB. Kit or use of the set of 3 or more primers and probes to determine the expression levels of 3 or more genes of the AR cellular signalling pathway and optionally from a cellular signalling pathway selected from the ER, PI3K-FOXO, MAPK-AP1, Notch, HH, TGFbeta, WNT, PR, NFkB, JAK-STAT1/2 and JAK-STAT3 pathways wherein the expression levels of three or more of the reference genes selected from: ACTB, ALAS1, B2M, EEF1A1, POLR2A, PUM1, RPLPO, TBP, TPT1 and TUBA1B may also be determined.