CHIMERIC ANTI-HUMAN BRAF V600E ANTIBODIES AND METHODS FOR MAKING AND USING THEM

In alternative embodiments, provided are chimeric or recombinant anti-human BRAF V600E antibodies, including products of manufacture and kits comprising them, and methods for making and using them, including for example their use in the detection or diagnosis of a cancer or other condition. In alternative embodiments, anti-BRAF V600E antibodies as provided herein are used together with an agent for determining whether MLH1 expression or activity is reduced or absent. In further alternative embodiments, anti-BRAF V600E antibodies as provided herein are used together with antibodies which specifically bind at least one protein selected from the group consisting of MLH1, PMS2, MSH2 and MSH6 to differentiate between Sporadic Colorectal Cancer (CRC) and probable Lynch syndrome.