(AZA)QUINOLINE 4-AMINES DERIVATIVES AS P2X3 INHIBITORS

(AZA)QUINOLINE 4-AMINES DERIVATIVES AS P2X3 INHIBITORS

The present invention relates to compounds of formula (I) inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are (aza)quinoline 4-amines derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The com...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BAKER-GLENN, Charles, BRUNO, Paolo, FIORELLI, Claudio, VAN DE POËL, Hervè, BIAGETTI, Matteo
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to compounds of formula (I) inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are (aza)quinoline 4-amines derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).