CARIPRAZINE PHARMACEUTICAL COMPOSITION, PREPARATION METHOD AND APPLICATION THEREOF

CARIPRAZINE PHARMACEUTICAL COMPOSITION, PREPARATION METHOD AND APPLICATION THEREOF

A pharmaceutical composition containing cariprazine, a preparation method and an application thereof are provided. The pharmaceutical composition contains cariprazine pamoate solid particles. A particle size of the cariprazine solid particles has a Dv(10) less than or equal to 30 microns, a Dv(50) l...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: YING, Shuhuan, CHEN, Zhixiang, ZHU, Tao, ZHANG, Xian, WANG, Tingting
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A pharmaceutical composition containing cariprazine, a preparation method and an application thereof are provided. The pharmaceutical composition contains cariprazine pamoate solid particles. A particle size of the cariprazine solid particles has a Dv(10) less than or equal to 30 microns, a Dv(50) less than or equal to 50 microns, and a Dv(90) less than or equal to 100 microns. When being used, the pharmaceutical composition containing cariprazine is an aqueous suspension and, the concentration of the free base of cariprazine is moderate. A long-term effect can be achieved upon injection of a certain administration volume of the pharmaceutical composition, thereby reducing the frequency of medication while increasing patient medication compliance. Furthermore, the pharmaceutical composition has a high bioavailability and has promising marketing prospects.