PROCESS FOR PREPARATION OF CHROMATOGRAPHY MEMBRANES

PROCESS FOR PREPARATION OF CHROMATOGRAPHY MEMBRANES

A method for producing a chromatography medium by:a) exposing a nanoweb sheet having mean flow pore size from 0.1 to 5 μm and a porosity from 40 to 90 volume % to a gaseous phase comprising a vinyl monomer to produce a functionalized nanoweb sheet;b) layering a plurality of functionalized nanoweb sh...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dharia, Jayesh, Ostrander, Michael
Format: Patent
Sprache:eng
Schlagworte:
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
SEPARATION
THEIR RELEVANT APPARATUS
TRANSPORTING
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Beschreibung
Zusammenfassung:A method for producing a chromatography medium by:a) exposing a nanoweb sheet having mean flow pore size from 0.1 to 5 μm and a porosity from 40 to 90 volume % to a gaseous phase comprising a vinyl monomer to produce a functionalized nanoweb sheet;b) layering a plurality of functionalized nanoweb sheets to form a functionalized nanoweb stack;c) cutting the functionalized nanoweb stack with a die to form die-cut functionalized nanoweb stacks having regular shapes; andd) exposing the die-cut functionalized nanoweb stacks in an aqueous medium to a ligand such as a protein which is capable of forming covalent bonds.