CHIMERIC PROTEIN COMPRISING THE RECEPTOR BINDING DOMAIN OF THE CORONA VIRUS SPIKE PROTEIN AND COMPOSITIONS COMPRISING THEM

CHIMERIC PROTEIN COMPRISING THE RECEPTOR BINDING DOMAIN OF THE CORONA VIRUS SPIKE PROTEIN AND COMPOSITIONS COMPRISING THEM

The present invention provides a chimeric protein that has a modular structure and comprises a receptor binding domain (RBD) from the spike protein (S) of coronaviruses, a segment able to bind the core antigen from the Hepatitis B Virus (HBcAg), a segment including six consecutive histidine residues...

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Bibliographische Detailangaben
Hauptverfasser: AYALA ÁVILA, Marta, HUERTA GALINDO, Vivian, GONZÁLEZ ROCHE, Diamilé, MUSACCHIO LASA, Alexis, MARTÍN DUNN, Alejandro Miguel, BEQUET ROMERO, Mónica, MARQUEZ PERERA, Gabriel J, CHINEA SANTIAGO, Glay, SANTANA MILIAN, Héctor, PIMENTEL VAZQUEZ, Eulogio, IGLESIAS PÉREZ, Enrique, LIMONTA FERNÁNDEZ, Miladys, CABRALES RICO, Ania, GUILLEN NIETO, Gerardo Enrique, ROJAS DORANTES, Gertrudis
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides a chimeric protein that has a modular structure and comprises a receptor binding domain (RBD) from the spike protein (S) of coronaviruses, a segment able to bind the core antigen from the Hepatitis B Virus (HBcAg), a segment including six consecutive histidine residues (HHHHHH), and two spacer segments. In this chimeric protein the aforementioned segments are arranged in a specific order, and the protein is able to form hybrid nanoparticles with HBcAg. The chimeric protein is part of vaccine compositions used for the prevention of coronavirus infections. Therefore, the invention discloses a method for the prevention of coronavirus infections, whereby a vaccine composition comprising said chimeric protein is administered.