TRANSFORMED IMMUNE CELLS INDUCING CHEMOTAXIS TOWARDS HETEROGENEOUS IMMUNE CELLS

Immune cells expressing IL-7, CCL19, or a combination thereof, and a composition containing the immune cells, which is useful for preventing or treating cancer or infectious diseases are disclosed. A method for preventing or treating cancer or infectious diseases, which include administering a thera...

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Bibliographische Detailangaben
Hauptverfasser:	LEE, Milim, SON, Dohyun, CHOI, Ki Doo, OH, Sanghyeon
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Immune cells expressing IL-7, CCL19, or a combination thereof, and a composition containing the immune cells, which is useful for preventing or treating cancer or infectious diseases are disclosed. A method for preventing or treating cancer or infectious diseases, which include administering a therapeutically effective amount of single type of immune cells, specifically natural killer cells, is also disclosed. Complementary immune responses between the patient's endogenous T cells and injected natural killer cells exhibit multifaceted and synergistic therapeutic effects. Co-administration of T cells and the immune cells other than T cells, specifically natural killer cells, also significantly improves therapeutic effects by allowing these heterogeneous cell populations to act in a lesion-concentrated manner.