ORTHOGONAL IL-21 RECEPTOR/CYTOKINE SYSTEMS

ORTHOGONAL IL-21 RECEPTOR/CYTOKINE SYSTEMS

Orthogonal IL-21 receptors and orthogonal IL-21 cytokines are described. The IL-21 receptor-cytokine pairs may include an orthogonal interleukin-21 receptor α chain ("ortho-IL-21Rα") that has impaired binding to native interleukin-21 cytokine ("IL-21") and an orthogonal IL-21 cyt...

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Bibliographische Detailangaben
Hauptverfasser: Beske, Oren, Govindarajan, Sridhar, Killeen, Nigel, Vollrath, Benedikt K
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:Orthogonal IL-21 receptors and orthogonal IL-21 cytokines are described. The IL-21 receptor-cytokine pairs may include an orthogonal interleukin-21 receptor α chain ("ortho-IL-21Rα") that has impaired binding to native interleukin-21 cytokine ("IL-21") and an orthogonal IL-21 cytokine ("ortho-IL-21") that has impaired binding to native IL-21Rα, wherein the ortho-IL-21Rα binds to the ortho-IL-21. The IL-21 receptor-cytokine pair may activate IL-21 signaling. Cells engineered to express the orthogonal IL-21 receptors are also described, as well as methods for using such cells for treatment of various diseases and disorders.