Method, Compositions and Applications of Mechanosensitive Channels

The present invention generally relates to the novel method, compositions and applications of mechanosensitive channels in therapeutics for visual, neurological and other disorders. Specifically, the invention relates to exploitation of mechanosensitive channels' intrinsic property as a transgenic pressure modulator and alternative outflow actuator in the treatment of different diseases such as glaucoma, blood pressure and other diseases involving of cells prone to mechanical or osmotic stress. Furthermore, the invention relates to exploitation of mechanosensitive channels for stimulation of cells enabling therapies for different diseases including pain, as well as molecular delivery to cells triggered by internal and/or external mechanical stimuli.