Disaggregation of processing pipeline

A method for processing includes receiving a definition of a processing pipeline including multiple sequential processing stages. The processing pipeline is partitioned into a plurality of partitions. The first partition of the processing pipeline is executed on a first computational accelerator, whereby the first computational accelerator writes output data from a final stage of the first partition to an output buffer in a first memory. The output data are copied over a packet communication network to an input buffer in a second memory. The second partition of the processing pipeline is executed on a second computational accelerator using the copied output data in the second memory as input data to a first stage of the second partition.