ANTI-TN-MUC1 CHIMERIC ANTIGEN RECEPTORS

The present invention relates to improved compositions and methods for treating diseases, such as cancers that express aberrantly glycosylated MUC1 proteins, by providing a cell immunotherapy, wherein the cell immunotherapy is an immunomodulatory cell expressing a chimeric antigen receptor (CAR) tha...

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Bibliographische Detailangaben
Hauptverfasser: BHINDER, Tejinder Kaur, LEKOMTSEV, Sergey, CHRIST, Nicole, LEWIS, ALAN Peter
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to improved compositions and methods for treating diseases, such as cancers that express aberrantly glycosylated MUC1 proteins, by providing a cell immunotherapy, wherein the cell immunotherapy is an immunomodulatory cell expressing a chimeric antigen receptor (CAR) that binds aberrantly glycosylate MUC1 proteins. The invention further relates to polynucleotides, expression vectors, and immunomodulatory cells comprising the immunotherapy, as well as related methods.